[AGL] Fw: More on prostate cancer

[Bill Irwin]

This is a topic on the other list and is important so I am forwarding it so that all can benefit.


Don:

You are defiantly on to something here with the relationship of Prostrate cancer (PC) and calcium.  After reading your letter I did a little research on your subject of PC and bone density.  What you are saying is true, in fact PC seems to have quite an effect on the metabolism of calcium.  Not only does bone density have a relationship to PC but low vitamin D levels also have a relationship to PC.  Vitamin D and calcium are closely tied together in metabolism.  PC cells may be killed by calcium, Vitamin D can prevent and cure PC.  There seems to be all sorts of relationships between the three.  Where there is PC there is some pathology in calcium metabolism.  One thing I learned is that too much calcium intake may be a cause of PC (still some controversy on this point) and the cure for the problem is taking Vitamin D.

I have attached some links below that deal with the subject.  Vitamin D is also useful in the prevention and treatment of breast and colon cancer so is a subject for both men and women.

Some suggestions on the use of Vitamin D in the treatment and prevention of PC:  For healthy young and middle aged people without cancer the recommended dose is about 400 IU.  For seniors living in northern climates without much exposure to the sun 400-800 IU is recommended.  If you do have active PC consider much higher doses such as 1500-2000 IU for sort or intermediate term dosage.  Long term dosage over about 1000 IU could cause problems down the road.  If you do have cancer the risk of the cancer is more dangerous that a little too much vitamin D.   An important consideration in Vitamin D supplements is how much you are taking and Vitamin D is in so many products that it is easy to find yourself taking too much.  Vitamin D is add to many products and often pops up in unexpected places.  It's in milk, cereals and many other products.  If you are taking any of the following be sure and read the labels and figure out how much you are really getting - calcium supplements, preparations for bone health or strength, many products for "male health", some calcium antacids, multi-vitamins, and a whole host of herbal preparations.  It all adds up so count what you are now taking before adding more.  If you spend a lot of time in the sun this will also decrease the Vitamin D you will need to take.

Calcium supplements many not be good for older men.

I am working on a longer report on supplements that may prevent/cure PC,  may take a while.

This letter is for Dave, Wayne, and the rest of us that have not yet been diagnosed with PC.  Both men and women should be taking Vitamin D as both PC and breast cancer are helped by Vitamin D.  To prevent/cure cancer you will also need the B vitamins to keep your biochemical factory to top shape and please don't forget to take Beta Glucan to keep the immune system healthy.  The immune system is the most important system if you want to prevent or cure cancer.  Dave and Wayne - please take Beta Glucan.

Aloha,

Ewie

PS - A question for Don - Did you at one time take a calcium supplement?

The reading list:  Difficult reading but you life is at stake.

http://www3.interscience.wiley.com/cgi-bin/abstract/49067/ABSTRACT?CRETRY=1&SRETRY=0

These findings indicate that androgen independent prostate tumor cell lines express multiple receptors capable of elevating intracellular calcium, and suggest that GRP receptors may be selectively expressed and/or coupled to calcium signaling during prostate tumor progression. Calcium sensitive cellular events may therefore contribute to the progression of prostate cancer

http://epirev.oxfordjournals.org/cgi/reprint/23/1/87.pdf

Dairy Products, Calcium, and Vitamin D and Risk of Prostate Cancer

In summary, there is reasonable evidence that both vitamin D metabolites and calcium, and specifically calcium from dairy sources, play important roles in the development of prostate cancer. Given current national enthusiasm to increase calcium consumption in efforts to prevent other chronic diseases (e.g., osteoporosis), further study of these factors is warranted, particularly in aging men. Additional studies that assess serum vitamin D metabolites, vitamin D binding proteins, VDR polymorphisms, dietary and supplemental calcium intakes, and phosphorous intake are recommended. (Note: this article claims a link between PC an dairy intake but some other studies say there is no link.)

http://intl-cebp.aacrjournals.org/cgi/content/abstract/12/7/597

Our results support the hypothesis that very high calcium intake, above the recommended intake for men, may modestly increase risk of prostate cancer. 


http://www.ebmonline.org/cgi/content/abstract/221/2/89
Classically, the actions of vitamin D have been associated with bone and mineral metabolism. More recent studies have shown that vitamin D metabolites induce differentiation and/or inhibit cell proliferation of a number of malignant and nonmalignant cell types including prostate cancer cells. Epidemiological studies show correlations between the risk factors for prostate cancer and conditions that can result in decreased vitamin D levels. The active metabolite of vitamin D, 1,25- dihydroxyvitamin D3 (calcitriol), inhibits growth of both primary cultures of human prostate cancer cells and cancer cell lines, but the mechanism by which the cells are growth-inhibited has not been clearly defined. Initial studies suggest that calcitriol alters cell cycle progression and may also initiate apoptosis

http://www3.interscience.wiley.com/cgi-bin/abstract/101523798/ABSTRACT?CRETRY=1&SRETRY=0
Prostate cancer (PCa) cells express vitamin D receptors (VDR) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits the growth of epithelial cells derived from normal, benign prostate hyperplasia, and PCa as well as established PCa cell lines. ............. A small clinical trial has shown that 1,25(OH)2D3 can slow the rate of prostate specific antigen (PSA) rise in PCa patients demonstrating proof of concept that 1,25(OH)2D3 exhibits therapeutic activity in men with PC.......

http://jn.nutrition.org/cgi/content/full/133/7/2461S
Pathways Mediating the Growth-Inhibitory Actions of Vitamin D in Prostate Cancer.
Vitamin D is emerging as an important dietary factor that affects the incidence and progression of many malignancies including prostate cancer. The active form of vitamin D, 1,25-dihydroxycholecalciferol [1,25(OH)2D3], inhibits the growth and stimulates the differentiation of prostate cancer cells.

http://cebp.aacrjournals.org/cgi/content/abstract/6/9/727
 These findings support the hypothesis that 1,25 D reduces the risk of invasive prostate cancer and suggest a role for vitamin D compounds in the chemoprevention of invasive prostate cancer. 


  ----- Original Message ----- 
  From: Don Laird 
  To: GHETTO2 at LISTS.WHATHELPS.COM 
  Sent: Saturday, December 02, 2006 12:36 PM
  Subject: More on prostate cancer


  There is an amazing and unfortunate correlation between prostate cancer (PC) and bone mineral density (BMD) such that in one fairly representative study it was found that at the time of diagnosis of PC, 63% of the men had osteoporosis and an additional 32% had osteopenia!  The study also looked at measures of bone density and found that the commonplace DEXA BMD measure typically fails to identify osteopenia.  The superior measure - quantitative computerized tomography - should be used, but most MDs don’t know about it.  (You can’t rule out osteopenia if you’ve not lost height, but if you have, you may very well have it.)

   

  Abnormal bone density is also related to increased risk of cardiovascular disease, kidney stone formation, Alzheimer’s disease, and possible stimulation of PC (and breast cancer).

   

  I have osteopenia, which in my opinion is related to my low testosterone level for probably several years.  The disgusting endocrinologist I saw failed to mention any of these risks, although she invited me to have her treat my bone condition.

   

  The important implication to me of this bone/PC relationship is that any condition may be likely to have a greater impact on health than you imagine.  

   

  Here are a couple of related sources:

   

    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=17084167 

   

    http://cat.inist.fr/?aModele=afficheN&cpsidt=16035805  

   

  Don



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